ALLELE-SPECIFIC GENE PROBING SUPPORTS THE DQ MOLECULE AS A DETERMINANT OF INHERITED SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS

被引：31

作者：

JENKINS, D

MIJOVIC, C

JACOBS, KH

PENNY, MA

FLETCHER, J

BARNETT, AH

机构：

[1] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

DIABETOLOGIA | 1991年 / 34卷 / 02期

基金：

英国惠康基金;

关键词：

TRANSRACIAL STUDIES; NORTH INDIANS; GENE PROBING; HLA-DQ; TYPE-1 (INSULIN-DEPENDENT) DIABETES;

D O I：

10.1007/BF00500381

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of inherited protection against Type 1 diabetes (RR = 0.12, p(c) < 0.05). The A3 allele of the DQA1 gene was positively associated with the disease, (RR = 3.6, p(c) < 0.05), as was the DQw2 allele of the DQB1 gene (RR = 4.6, p(c) < 0.01). Trans-racial comparison of these disease associations indicates that DQ alleles may directly determine an element of inherited susceptibility to Type 1 diabetes.

引用

页码：109 / 113

页数：5

共 24 条

[21] IDENTIFICATION OF SUSCEPTIBILITY LOCI FOR INSULIN-DEPENDENT DIABETES-MELLITUS BY TRANS-RACIAL GENE-MAPPING [J].