SOLID-PHASE SYNTHESIS OF AN RNA NUCLEOPEPTIDE FRAGMENT FROM THE NUCLEOPROTEIN OF POLIOVIRUS

被引：23

作者：

DREEFTROMP, CM ^{[1
]}

VANDENELST, H ^{[1
]}

VANDENBOOGAART, JE ^{[1
]}

VANDERMAREL, GA ^{[1
]}

VANBOOM, JH ^{[1
]}

机构：

[1] GORLAEUS LABS, POB 9502, 2300 RA LEIDEN, NETHERLANDS

来源：

NUCLEIC ACIDS RESEARCH | 1992年 / 20卷 / 10期

关键词：

D O I：

10.1093/nar/20.10.2435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The naturally occurring RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 is prepared via a solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides. Preliminary H-1-NMR studies show that the peptidyl unit has a remarkable effect on the conformational behaviour of the RNA moiety in the nucleopeptide.

引用

页码：2435 / 2439

页数：5

共 23 条

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