SOMATOSTATIN RECEPTOR SUBTYPE SSTR2 MEDIATES THE INHIBITION OF HIGH-VOLTAGE-ACTIVATED CALCIUM CHANNELS BY SOMATOSTATIN AND ITS ANALOG SMS-201-995

被引：46

作者：

FUJII, Y

GONOI, T

YAMADA, Y

CHIHARA, K

INAGAKI, N

SEINO, S

机构：

[1] CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV MOLEC MED,CHUO KU,CHIBA 260,JAPAN

[2] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHIBA 260,JAPAN

[3] KYOTO UNIV,SCH MED,DEPT METAB & CLIN NUTR,KYOTO 606,JAPAN

[4] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN

来源：

FEBS LETTERS | 1994年 / 355卷 / 02期

关键词：

SOMATOSTATIN ANALOG; SOMATOSTATIN RECEPTOR SUBTYPE; VOLTAGE-DEPENDENT CALCIUM CHANNEL; G-PROTEIN; INTRACELLULAR CALCIUM;

D O I：

10.1016/0014-5793(94)01159-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Somatostatin and its anologue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.

引用

页码：117 / 120

页数：4

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