SOMATOSTATIN RECEPTOR SUBTYPE SSTR2 MEDIATES THE INHIBITION OF HIGH-VOLTAGE-ACTIVATED CALCIUM CHANNELS BY SOMATOSTATIN AND ITS ANALOG SMS-201-995

被引：46

作者：

FUJII, Y

GONOI, T

YAMADA, Y

CHIHARA, K

INAGAKI, N

SEINO, S

机构：

[1] CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV MOLEC MED,CHUO KU,CHIBA 260,JAPAN

[2] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHIBA 260,JAPAN

[3] KYOTO UNIV,SCH MED,DEPT METAB & CLIN NUTR,KYOTO 606,JAPAN

[4] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN

来源：

FEBS LETTERS | 1994年 / 355卷 / 02期

关键词：

SOMATOSTATIN ANALOG; SOMATOSTATIN RECEPTOR SUBTYPE; VOLTAGE-DEPENDENT CALCIUM CHANNEL; G-PROTEIN; INTRACELLULAR CALCIUM;

D O I：

10.1016/0014-5793(94)01159-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Somatostatin and its anologue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.

引用

页码：117 / 120

页数：4

共 27 条

[11] ASSIGNMENT OF G-PROTEIN SUBTYPES TO SPECIFIC RECEPTORS INDUCING INHIBITION OF CALCIUM CURRENTS
KLEUSS, C
HESCHELER, J
EWEL, C
ROSENTHAL, W
SCHULTZ, G
WITTIG, B
[J]. NATURE, 1991, 353 (6339) : 43 - 48
[12] SELECTIVITY IN SIGNAL TRANSDUCTION DETERMINED BY GAMMA-SUBUNITS OF HETEROTRIMERIC G-PROTEINS
KLEUSS, C
SCHERUBL, H
HESCHELER, J
SCHULTZ, G
WITTIG, B
[J]. SCIENCE, 1993, 259 (5096) : 832 - 834
[13] THE SOMATOSTATIN RECEPTOR IS DIRECTLY COUPLED TO ADENYLATE-CYCLASE IN GH4C1 PITUITARY CELL-MEMBRANES
KOCH, BD
SCHONBRUNN, A
[J]. ENDOCRINOLOGY, 1984, 114 (05) : 1784 - 1790
[14] IDENTIFICATION OF SOMATOSTATIN RECEPTOR SUBTYPES AND AN IMPLICATION FOR THE EFFICACY OF SOMATOSTATIN ANALOG SMS-201-995 IN TREATMENT OF HUMAN ENDOCRINE TUMORS
KUBOTA, A
YAMADA, Y
KAGIMOTO, S
SHIMATSU, A
IMAMURA, M
TSUDA, K
IMURA, H
SEINO, S
SEINO, Y
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) : 1321 - 1325
[15] THE ROLE OF SOMATOSTATIN AND ITS ANALOGS IN THE DIAGNOSIS AND TREATMENT OF TUMORS
LAMBERTS, SWJ
KRENNING, EP
REUBI, JC
[J]. ENDOCRINE REVIEWS, 1991, 12 (04) : 450 - 482
[16] A GUANINE NUCLEOTIDE-BINDING PROTEIN MEDIATES THE INHIBITION OF VOLTAGE-DEPENDENT CALCIUM CURRENT BY SOMATOSTATIN IN A PITUITARY CELL-LINE
LEWIS, DL
WEIGHT, FF
LUINI, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) : 9035 - 9039
[17] G-PROTEIN ACTIVATION OF A HORMONE-STIMULATED PHOSPHATASE IN HUMAN TUMOR-CELLS
PAN, MG
FLORIO, T
STORK, PJS
[J]. SCIENCE, 1992, 256 (5060) : 1215 - 1217
[18] RELATIONSHIPS BETWEEN CALCIUM AND CYCLIC NUCLEOTIDES IN CELL ACTIVATION
RASMUSSEN, H
GOODMAN, DBP
[J]. PHYSIOLOGICAL REVIEWS, 1977, 57 (03) : 421 - 509
[19] SOMATOSTATIN .1.
REICHLIN, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (24) : 1495 - 1501
[20] SOMATOSTATIN .2.
REICHLIN, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (25) : 1556 - 1563

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