SYNTHESIS, RADIOLABELING AND STABILITY OF RADIOIODINATED M-IODOBENZYLGUANIDINE, A REVIEW

被引：25

作者：

WAFELMAN, AR

KONINGS, MCP

HOEFNAGEL, CA

MAES, RAA

BEIJNEN, JH

机构：

[1] NETHERLANDS CANC INST,DEPT NUCL MED,1066 CX AMSTERDAM,NETHERLANDS

[2] UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT ANAL & TOXICOL,3584 CA UTRECHT,NETHERLANDS

来源：

APPLIED RADIATION AND ISOTOPES | 1994年 / 45卷 / 10期

关键词：

D O I：

10.1016/0969-8043(94)90168-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Since the introduction of radioiodinated m-iodobenzylguanidine in 1980, much research has been performed, both in the chemical field as well as in medical sciences. This paper reviews the synthesis, radiolabelling and stability of radioiodinated m-iodobenzylguanidine. Regarding the many radiolabelling procedures for m-iodobenzylguanidine, the Cu1+-assisted nucleophilic exchange radioiodination can be considered as the method of first choice. Quality control of the radiopharmaceutical product is discussed and attention is paid to recent studies regarding the radiochemical stability of iodine-131 labelled m-iodobenzylguanidine.

引用

页码：997 / 1007

页数：11

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