DIRECT DIFFERENTIAL PULSE POLAROGRAPHIC AND ADSORPTIVE STRIPPING VOLTAMMETRIC ASSAY OF KETOTIFEN IN TABLETS

被引：9

作者：

BERSIER, PM

SZCZEPANIAK, W

REN, M

机构：

[1] CIBA GEIGY AG,CENT ANALYT LAB,CH-4002 BASEL,SWITZERLAND

[2] ADAM MICKIEWICZ UNIV,FAC CHEM,DEPT INSTRUMENTAL ANAL,PL-60780 POZNAN,POLAND

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 05期

关键词：

D O I：

10.1002/ardp.19923250502

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Direct differential pulse polarography allows the determination of the content uniformity of ketotifen (1) in single Zitaden(R) 1 mg tablets using the reduction wave of the keto moietY. 1N H2SO4 is used as solvent and supporting electrolyte. By adsorptive stripping voltammetry (AdSV) the ketotifen concentration of complex "Positan" (Polfa-Poznan) samples can be determined directly without preliminary separation of excipients. Analysis of (1) in urine is carried out by AdSV after a preliminary solid phase extraction. In model solutions as little as 2.5 . 10(-9) M ketotifen hydrogen fumarate can be determined by AdSV.

引用

页码：253 / 259

页数：7

共 23 条

[1]

[Anonymous], 1985, STRIPPING ANAL PRINC

[2]

BERSIER PM, IN PRESS BIOELECTRFO

[3] COMBINATION OF TLC, GLC (OV1 AND OV17) AND HPLC (RP18) FOR A RAPID DETECTION OF DRUGS AND RELATED-COMPOUNDS [J].

DALDRUP, T ;

SUSANTO, F ;

MICHALKE, P .

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1981, 308 (05) :413-427

[4]

Daldrup T., 1982, CHROMATOGR NEWSL, V10, P1

[5] DETERMINATION OF AMINES USING THE FLUORIMETRIC ION-PAIR TECHNIQUE AS A POST-COLUMN REACTOR FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GFELLER, JC ;

FREY, G ;

HUEN, JM ;

THEVENIN, JP .

JOURNAL OF CHROMATOGRAPHY, 1979, 172 (APR) :141-151

[6]

GUERRET M, 1981, CR C EUR BIOPHARM PH, V2, P317

[7]

Hoogewijs G, 1984, J Pharm Biomed Anal, V2, P449, DOI 10.1016/0731-7085(84)80048-5

[8] QUANTIFICATION OF KETOTIFEN AND ITS METABOLITES IN HUMAN-PLASMA BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

JULIENLAROSE, C ;

GUERRET, M ;

LAVENE, D ;

KIECHEL, JR .

BIOMEDICAL MASS SPECTROMETRY, 1983, 10 (03) :136-142

[9]

JULIENLAROSE C, 1981, C R C EUR BIOPHARM P, V1, P326

[10] OSZILLOPOLAROGRAPHISCHES VERHALTEN EINIGER CARBONYLVERBINDUNGEN [J].

KALVODA, R ;

BUDNIKOV, G .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1963, 28 (04) :838-+

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