DIRECT DIFFERENTIAL PULSE POLAROGRAPHIC AND ADSORPTIVE STRIPPING VOLTAMMETRIC ASSAY OF KETOTIFEN IN TABLETS

被引：9

作者：

BERSIER, PM

SZCZEPANIAK, W

REN, M

机构：

[1] CIBA GEIGY AG,CENT ANALYT LAB,CH-4002 BASEL,SWITZERLAND

[2] ADAM MICKIEWICZ UNIV,FAC CHEM,DEPT INSTRUMENTAL ANAL,PL-60780 POZNAN,POLAND

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 05期

关键词：

D O I：

10.1002/ardp.19923250502

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Direct differential pulse polarography allows the determination of the content uniformity of ketotifen (1) in single Zitaden(R) 1 mg tablets using the reduction wave of the keto moietY. 1N H2SO4 is used as solvent and supporting electrolyte. By adsorptive stripping voltammetry (AdSV) the ketotifen concentration of complex "Positan" (Polfa-Poznan) samples can be determined directly without preliminary separation of excipients. Analysis of (1) in urine is carried out by AdSV after a preliminary solid phase extraction. In model solutions as little as 2.5 . 10(-9) M ketotifen hydrogen fumarate can be determined by AdSV.

引用

页码：253 / 259

页数：7

共 23 条

[11] ADSORPTIVE STRIPPING VOLTAMMETRY IN TRACE ANALYSIS [J].