ON THE RELATION OF CALCIUM-CHANNEL BLOCKERS TO RAT PAROTID AND SUBMANDIBULAR GLANDS FUNCTION IN-VIVO

被引：14

作者：

DEHPOUR, AR

GHAFOURIFAR, P

MASSOUDI, S

ABDOLLAHI, M

MOUSAVIZADEH, K

机构：

[1] Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1995年 / 26卷 / 03期

关键词：

NIFEDIPINE; VERAPAMIL; DILTIAZEM SALIVARY GLAND; RAT;

D O I：

10.1016/0306-3623(94)00195-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of nifedipine, verapamil and diltiazem on rat parotid and submandibular glands function were studied. 2. Nifedipine (5 mg/kg), verapamil (5 mg/kg) and diltiazem (10 mg/kg) were injected intraperitoneally 15 min before saliva collection. 3. Animals were anesthetized with 50 mg/kg of sodium pentobarbital and 8 mg/kg of pilocarpine was used as secretagogue. 4. Submandibular saliva was analyzed for flow rate, protein and calcium concentrations; and parotid saliva for calcium and amylase contents. 5. In treated groups, flow rate and calcium of submandibular saliva were significantly lower than controls. Parotid calcium in the nifedipine group was decreased and in verapamil and diltiazem groups was increased. Parotid amylase was significantly decreased in both the nifedipine and diltiazem groups. 6. It is concluded that a blockade of calcium channels in salivary glands acinar cells by CCBs causes some alterations in salivary secretions.

引用

页码：619 / 622

页数：4

共 32 条

[21]

Rossignol, Herman, Chambaut, Keryer, The calcium ionophore A 23 187 as a probe for studying the role of Ca2+ ions in the mediation of carbachol effects on rat salivary glands: protein secretion and metabolism of phospholipids and glycogen, FEBS Lett., 43, 2, pp. 241-246, (1974)

[22]

Rossignol, Herman, Keryer, Inhibition by colchicine of carbamylcholine-induced glycoprotein secretion by submaxillary gland, A possible mechanism of cholinergic induced protein secretion, 21, pp. 189-194, (1972)

[23]

Slimak, Stark, Egan, Jensen, Gardner, Effect of verapamil on the cyclic AMP-mediated pathway for amylase secretion in rat pancreatic acini, Pancreas, 8, 2, pp. 212-219, (1993)

[24]

Sooriamoorthy, Gower, Eley, Androgen metabolism in gingival hyperplasia induced by nifedipine and cyclosporin, Journal of Periodontal Research, 25, 1, pp. 25-30, (1990)

[25]

Suddick, Schannon, Salivary Na, K and C1 secretion rates: relationship to a fluid generation mechanism, Jpn. J. Physiol., 20, pp. 540-549, (1970)

[26]

Tagawa, Nakamura, Murata, Marked gingival hyperplasia induced by nifedipine, Int. J. Oral Maxillofac. Surg., 19, 2, pp. 72-73, (1990)

[27]

Taylor, Cholinergic agonists, In The Pharmacological Basis of Therapeutics, 2, pp. 1237-1238, (1990)

[28]

Valdez, Turner, Effects of secretagogues on cytosolic Ca2+ levels in rat submandibular granular ducts and acini, Am. J. Physiol. Gastrointest. Liver Physiol., 261, 2, (1991)

[29]

Valdez, Turner, Effects of secretagogues on cytosolic Ca2+ levels in rat submandibular granular ducts and acini, Am. J. Physiol. Gastrointest. Liver Physiol., 261, 2, pp. G359-G363, (1991)

[30]

Wong, Foskett, Oscillations of cytosolic sodium during calcium oscillations in exocrine acinar cells, Science, 254, 5034, pp. 1014-1016, (1991)

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