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DISPARATE EFFECT OF TAMOXIFEN IN RATS WITH EXPERIMENTALLY INDUCED ENDOMETRIOSIS
被引:10
作者
:
KADABA, R
论文数:
0
引用数:
0
h-index:
0
机构:
Reproductive Biology Research Unit, Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, SK
KADABA, R
SIMPSON, CW
论文数:
0
引用数:
0
h-index:
0
机构:
Reproductive Biology Research Unit, Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, SK
SIMPSON, CW
机构
:
[1]
Reproductive Biology Research Unit, Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, SK
来源
:
ENDOCRINOLOGY
|
1990年
/ 126卷
/ 06期
关键词
:
D O I
:
10.1210/endo-126-6-3263
中图分类号
:
R5 [内科学];
学科分类号
:
1002 ;
100201 ;
摘要
:
The effect of tamoxifen on the growth of endometrial implants was examined in rats with experimentally induced endometriosis. Administration of tamoxifen (1 mg/kg-day) for 60 days completely regressed the endometrial implants. When tamoxifen treatment was withdrawn, recurrence of endometrial implants was observed. Ectopic endometrial implants regressed completely 2 months after ovariectomy inrats with experimentally induced endometriosis. Tamoxifen administration (1 mg/kg day) for 60 days to ovariectomized rats with regressed implants led to complete recurrence of ectopic endometrial implants. In ovariectomized rats administration of ta-moxifen antagonized estradiol-enhanced thymidine incorporation into uterine DNA, but tamoxifen per se stimulated thymidine incorporation. This indicates the agonist/antagonist nature of tamoxifen. Treatment of rats with tamoxifen blocked the normal estrous cycle. However, serumprogesterone levels were higher during tamoxifen treatment in rats with intact ovaries than in ovariectomized rats. When ovariectomized rats with regressed implants were administered tamoxifen (1 mg/kg-day) and progesterone (10 mg/kg day) for 60 days, recurrence of ectopic endometrial implants was not observed. These findings suggest that tamoxifen is effective in regressing endometrial implants in rats with experimentally induced endometriosis, and ovarian progesterone may have a facilatory effect. © 1990 by The Endocrine Society.
引用
收藏
页码:3263 / 3267
页数:5
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INTRAUTERINE INJECTION OF CHOLERA-TOXIN INDUCES ESTROGEN-LIKE UTERINE GROWTH
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UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
WEBSTER, RA
[J].
BIOLOGY OF REPRODUCTION,
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679
[22]
TAMOXIFEN IS A POTENT PURE ANTI-OESTROGEN IN CHICK OVIDUCT
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INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
MESTER, J
BAULIEU, EE
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0
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INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
BAULIEU, EE
[J].
NATURE,
1977,
267
(5610)
: 434
-
435
[23]
TAMOXIFEN INHIBITS OSTEOCLAST-MEDIATED RESORPTION OF TRABECULAR BONE IN OVARIAN HORMONE-DEFICIENT RATS
TURNER, RT
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LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
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LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
HANNON, KS
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0
h-index:
0
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LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
BELL, NH
[J].
ENDOCRINOLOGY,
1988,
122
(03)
: 1146
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1150
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ACTIVITY OF DEOXYRIBONUCLEIC-ACID POLYMERASE ALPHA STIMULATED BY ESTROGEN IN THE ENDOMETRIUM OF THE HUMAN-UTERUS DURING THE MENSTRUAL-CYCLE
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SHIODA, M
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[J].
GYNECOLOGICAL ENDOCRINOLOGY,
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[25]
NOVEL ANTIOESTROGENS WITHOUT PARTIAL AGONIST ACTIVITY
WAKELING, AE
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BOWLER, J
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31
(4B)
: 645
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653
←
1
2
3
→
共 25 条
[21]
INTRAUTERINE INJECTION OF CHOLERA-TOXIN INDUCES ESTROGEN-LIKE UTERINE GROWTH
STEWART, PJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
STEWART, PJ
WEBSTER, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
UNIV ILLINOIS,DEPT BIOL SCI,CHICAGO,IL 60680
WEBSTER, RA
[J].
BIOLOGY OF REPRODUCTION,
1983,
29
(03)
: 671
-
679
[22]
TAMOXIFEN IS A POTENT PURE ANTI-OESTROGEN IN CHICK OVIDUCT
SUTHERLAND, R
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
SUTHERLAND, R
MESTER, J
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
MESTER, J
BAULIEU, EE
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
INSERM,HORMONES LAB,U 33,F-94270 BICETRE,FRANCE
BAULIEU, EE
[J].
NATURE,
1977,
267
(5610)
: 434
-
435
[23]
TAMOXIFEN INHIBITS OSTEOCLAST-MEDIATED RESORPTION OF TRABECULAR BONE IN OVARIAN HORMONE-DEFICIENT RATS
TURNER, RT
论文数:
0
引用数:
0
h-index:
0
机构:
LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
TURNER, RT
WAKLEY, GK
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LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
WAKLEY, GK
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h-index:
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LOMA LINDA UNIV,PETTIS VET ADM HOSP,DEPT ORTHOPED,LOMA LINDA,CA 92354
BELL, NH
[J].
ENDOCRINOLOGY,
1988,
122
(03)
: 1146
-
1150
[24]
ACTIVITY OF DEOXYRIBONUCLEIC-ACID POLYMERASE ALPHA STIMULATED BY ESTROGEN IN THE ENDOMETRIUM OF THE HUMAN-UTERUS DURING THE MENSTRUAL-CYCLE
USUKI, S
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h-index:
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USUKI, S
KUBOTA, S
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h-index:
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KUBOTA, S
SHIODA, M
论文数:
0
引用数:
0
h-index:
0
SHIODA, M
[J].
GYNECOLOGICAL ENDOCRINOLOGY,
1988,
2
(04)
: 283
-
291
[25]
NOVEL ANTIOESTROGENS WITHOUT PARTIAL AGONIST ACTIVITY
WAKELING, AE
论文数:
0
引用数:
0
h-index:
0
WAKELING, AE
BOWLER, J
论文数:
0
引用数:
0
h-index:
0
BOWLER, J
[J].
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,
1988,
31
(4B)
: 645
-
653
←
1
2
3
→