SULFATIDE AND SULFATIDE ANTIBODIES IN INSULIN-DEPENDENT DIABETES-MELLITUS

被引：53

作者：

BUSCHARD, K

JOSEFSEN, K

HORN, T

FREDMAN, P

机构：

[1] MOLNDALS SJUKHUS,DEPT CLIN NEUROSCI,PSYCHIAT & NEUROCHEM SECT,MOLNDAL,SWEDEN

[2] HERLEV HOSP,DEPT PATHOL,DK-2730 HERLEV,DENMARK

来源：

LANCET | 1993年 / 342卷 / 8875期

关键词：

D O I：

10.1016/0140-6736(93)92697-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-dependent diabetes mellitus (IDDM) is associated with neurological disorders. Sulph I, a monoclonal antibody to sulphatide (a neural epitope), stained secretory granules in alpha and beta cells of rat islets of Langerhans, but not exocrine tissue. Sera from 88% of 57 newly diagnosed IDDM patients was anti-sulphatide positive, and 76% were positive 6 months later. All 135 healthy controls were negative. Sulphatide antibody may be an IDDM marker.

引用

页码：840 / 840

页数：1

共 8 条

[1]

BUSCHARD K, 1983, DIABETOLOGIA, V24, P42

[2] INSULIN AUTOANTIBODIES IN THE PREDIABETIC PERIOD - CORRELATION WITH ISLET CELL ANTIBODIES AND DEVELOPMENT OF DIABETES [J].