4 FURTHER ANTIBIOTICS RELATED TO OLIVANIC ACID PRODUCED BY STREPTOMYCES-OLIVACEUS - FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOSYNTHETIC-STUDIES

被引：55

作者：

BOX, SJ

HOOD, JD

SPEAR, SR

机构：

[1] Beecham Pharmaceuticals Research Division, Betchworth, Surrey, Brockham Park

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 12期

关键词：

D O I：

10.7164/antibiotics.32.1239

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four β-lactam antibiotics with β-lactamase inhibitory activity MM 22380, MM 22381, MM 22382 and MM 22383 containing the carbapenem nucleus have been isolated from a culture of Streptomyces olivaceus ATCC 31365. Fermentation conditions for their production and methods for their isolation are described. Evidence for a biosynthetic link between these compounds and the previously described olivanic acid derivatives MM 4550, MM 13902 and MM 17880 is presented. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：1239 / 1247

页数：9