CATALYSIS IN INVERTED POTENTIAL-ENERGY PROFILES

被引：2

作者：

EHRENBERG, M ^{[1
]}

TAPIA, O ^{[1
]}

机构：

[1] UNIV UPPSALA, DEPT PHYS CHEM, S-75121 UPPSALA, SWEDEN

来源：

BIOPHYSICAL CHEMISTRY | 1992年 / 43卷 / 02期

关键词：

CATALYSIS; ENZYME MECHANISMS; BROWNIAN MOTION IN POTENTIAL WELLS; CHEMICAL REACTION RATE THEORY; CATALYTIC INACTIVATION;

D O I：

10.1016/0301-4622(92)80030-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When the activated state of a substrate molecule is chemically similar to the ground states of substrate or product, enzymes are limited in their ability to stabilize the activated state. In conventional schemes this leads to slow catalysis. We present a model, based on two postulates, that removes this limitation. Here catalysis is based on a vibrational excitation along the S --> P transition, that is isolated from other dynamic modes of the protein. We discuss testable (verifiable) predictions of the model.

引用

页码：157 / 167

页数：11

共 45 条

[11] SLOW INACTIVATION OF RIBULOSEBISPHOSPHATE CARBOXYLASE DURING CATALYSIS IS CAUSED BY ACCUMULATION OF A SLOW, TIGHT-BINDING INHIBITOR AT THE CATALYTIC SITE [J].

EDMONDSON, DL ;

BADGER, MR ;

ANDREWS, TJ .

PLANT PHYSIOLOGY, 1990, 93 (04) :1390-1397

[12] THERMODYNAMIC CONSTRAINTS ON KINETIC PROOFREADING IN BIOSYNTHETIC PATHWAYS [J].

EHRENBERG, M ;

BLOMBERG, C .

BIOPHYSICAL JOURNAL, 1980, 31 (03) :333-358

[13] Some applications of the transition state method to the calculation of reaction velocities, especially in solution. [J].

Evans, MG ;

Polanyi, M .

TRANSACTIONS OF THE FARADAY SOCIETY, 1935, 31 (01) :0875-0893

[14] The activated complex in chemical reactions [J].

Eyring, H .

JOURNAL OF CHEMICAL PHYSICS, 1935, 3 (02) :107-115

[15]

Fersht A, 1984, ENZYME STRUCTURE MEC

[16] ENZYME HYPER-SPECIFICITY - REJECTION OF THREONINE BY VALYL-TRANSFER-RNA SYNTHETASE BY MIS-ACYLATION AND HYDROLYTIC EDITING [J].

FERSHT, AR ;

KAETHNER, MM .

BIOCHEMISTRY, 1976, 15 (15) :3342-3346

[17] RATE THEORIES AND PUZZLES OF HEMEPROTEIN KINETICS [J].

FRAUENFELDER, H ;

WOLYNES, PG .

SCIENCE, 1985, 229 (4711) :337-345

[18]

Haldane J. B. S., 1965, ENZYMES

[19] KINETIC PROOFREADING - NEW MECHANISM FOR REDUCING ERRORS IN BIOSYNTHETIC PROCESSES REQUIRING HIGH SPECIFICITY [J].

HOPFIELD, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) :4135-4139

[20] AN ABINITIO STUDY OF TRANSITION STRUCTURES AND ASSOCIATED PRODUCTS IN [ZNOHCO2]+, [ZNHCO3H2O]+, AND [ZN(NH3)3HCO3]+ HYPERSURFACES - ON THE ROLE OF ZINC IN THE CATALYTIC MECHANISM OF CARBONIC-ANHYDRASE [J].

JACOB, O ;

CARDENAS, R ;

TAPIA, O .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) :8692-8705

← 1 2 3 4 5 →