FUSACANDIN-A AND FUSACANDIN-B - NOVEL ANTIFUNGAL ANTIBIOTICS OF THE PAPULACANDIN CLASS FROM FUSARIUM-SAMBUCINUM .2. ISOLATION AND STRUCTURAL ELUCIDATION

Two novel antifungal compounds of the papulacandin class, named fusacandins A and B. have been isolated from Fusarium sambucinum. Each compound contains two units of galactose and one of glucose, the latter connected as a C-glycoside to an aromatic moiety. Fusacandin A is esterified at two sites with long-chain, unsaturated fatty acids and fusacandin B at only one site. The structures of the fusacandins were elucidated through analysis of mass spectral and 1-D and 2-D homonuclear and heteronuclear NMR data.