FUSACANDINS A AND B - NOVEL ANTIFUNGAL ANTIBIOTICS OF THE PAPULACANDIN CLASS FROM FUSARIUM-SAMBUCINUM .1. IDENTITY OF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY

被引：19

作者：

JACKSON, M ^{[1
]}

FROST, DJ ^{[1
]}

KARWOWSKI, JP ^{[1
]}

HUMPHREY, PE ^{[1
]}

DAHOD, SK ^{[1
]}

CHOI, WS ^{[1
]}

BRANDT, K ^{[1
]}

MALMBERG, LH ^{[1
]}

RASMUSSEN, RR ^{[1
]}

SCHERR, MH ^{[1
]}

FLAMM, RK ^{[1
]}

KADAM, S ^{[1
]}

MCALPINE, JB ^{[1
]}

机构：

[1] ABBOTT LABS,DIV CHEM & AGR PROD,N CHICAGO,IL 60064

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 07期

关键词：

D O I：

10.7164/antibiotics.48.608

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The fusacandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.

引用

页码：608 / 613

页数：6

共 16 条

[1]

BOOTH C, 1971, GENUS FUSARIUM, P168

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