REDUCED RESPONSIVENESS OF ADENYLATE-CYCLASE IN ALVEOLAR MACROPHAGES FROM PATIENTS WITH ASTHMA

被引：38

作者：

BACHELET, M ^{[1
]}

VINCENT, D ^{[1
]}

HAVET, N ^{[1
]}

MARRASHCHAHLA, R ^{[1
]}

PRADALIER, A ^{[1
]}

DRY, J ^{[1
]}

VARGAFTIG, BB ^{[1
]}

机构：

[1] HOP ROTHSCHILD,SERV MED INTERNE,F-75571 PARIS 12,FRANCE

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1991年 / 88卷 / 03期

关键词：

ADENYLATE CYCLASE; ALVEOLAR MACROPHAGES; ASTHMA;

D O I：

10.1016/0091-6749(91)90093-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Alveolar macrophages from patients with asthma accumulated less cyclic adenosine monophosphate when these macrophages were exposed to isobutyl methylxanthine, salbutamol, or prostaglandin E2, compared to cells from control subjects without asthma, and the degree of the hyporesponsiveness was related to the severity of asthma. In addition, a significantly lower adenylate cyclase activity was observed in crude membrane fractions of macrophages from the group with asthma in the presence of salbutamol and prostaglandin E2. The refractoriness observed in patients with asthma is thus not accounted for by a specific beta-adrenergic desensitization at the adenylate cyclase receptor level but should rather be explained by a cyclic adenosine monophosphate-dependent postreceptor mechanism.

引用

页码：322 / 388

页数：67