CHARACTERIZATION OF NONCOVALENT COMPLEXES BY ELECTROSPRAY MASS-SPECTROMETRY

被引：69

作者：

JAQUINOD, M

LEIZE, E

POTIER, N

ALBRECHT, AM

SHANZER, A

VANDORSSELAER, A

机构：

[1] UNIV STRASBOURG 1,SPECTROMETRIE MASSE BIOORGAN LAB,1 RUE B PASCAL,F-67008 STRASBOURG,FRANCE

[2] WEIZMANN INST SCI,DEPT ORGAN CHEM,IL-76100 REHOVOT,ISRAEL

[3] CNRS,PHYSICOCHIM BIOINORGAN LAB,STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)73558-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Electrospray Mass Spectrometry (ESMS) has been used to analyse protein/metal ion complexes directly in solution. A synthetic siderophore analogue and two sulphur-iron proteins have been used as models for the study of protein/iron interactions. These experiments were successfully extended to a protein/cofactor complex interaction model, myohemoglobin. Our results open the door to the characterization of weak interactions between large molecules by ESMS.

引用

页码：2771 / 2774

页数：4

共 12 条

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