EFFECT OF LIVER-PROTECTING SEMPERVIVUM-TECTORUM EXTRACT ON THE IMMUNE REACTIVITY OF SPLEEN-CELLS IN HYPERLIPEMIC RATS

被引：14

作者：

BLAZOVICS, A ^{[1
]}

GONZALEZCABELLO, R ^{[1
]}

BARTA, I ^{[1
]}

GERGELY, P ^{[1
]}

FEHER, J ^{[1
]}

KERY, A ^{[1
]}

PETRI, G ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED, SCH MED, INST PHARMACOGNOSY, H-1088 BUDAPEST, HUNGARY

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 01期

关键词：

SEMPERVIVUM TECTORUM; ANTIOXIDANT; CYTOKINES; HYPERLIPEMIA;

D O I：

10.1002/ptr.2650080108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pathobiological role of free radicals was demonstrated in hyperlipidaemia and in steatotic liver as well as in the immune response of lymphocytes and monocytes. Hyperlipidaemia has a suppressive effect on cellular immune responses, inhibits the mitogen induced lymphoblast transformation, diminishes the tumour necrosis factor alpha (TNF-alpha) production of spleen macrophages and enhances spontaneous interleukin 1 (IL-1) activity. A freeze dried extract of Sempervivum tectorum has antioxidant, free radical scavenger and membrane stabilizing effects. The measured serum parameters were changed favourably after Sempervivum tectorum extract treatment. The beneficial effect of Sempervivum tectorum extract was also observed on the Con A stimulated blast transformation of splenocytes, on the lipopolysaccharide (LPS) triggered TNF-alpha activity and on the spontaneous IL-1 activity of spleen macrophages of hyperlipidaemic rats. The natural scavenger capacity was increased by treatment, initiating restoration of liver function.

引用

页码：33 / 37

页数：5

共 29 条

[21] ELEVATED SERUM LEVELS OF TUMOR NECROSIS FACTOR ARE ASSOCIATED WITH PROGRESSIVE ENCEPHALOPATHY IN CHILDREN WITH ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

MINTZ, M ;

RAPAPORT, R ;

OLESKE, JM ;

CONNOR, EM ;

KOENIGSBERGER, MR ;

DENNY, T ;

EPSTEIN, LG .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1989, 143 (07) :771-774

[22]

MUZES G, 1989, LIVER, V9, P302

[23]

MUZES G, 1989, J CLIN LAB IMMUNOL, V30, P41

[24] THE EFFECT OF DIETARY SUPPLEMENTATION WITH VITAMIN-A, VITAMIN-C AND VITAMIN-E ON CELL-MEDIATED IMMUNE FUNCTION IN ELDERLY LONG-STAY PATIENTS - A RANDOMIZED CONTROLLED TRIAL [J].

PENN, ND ;

PURKINS, L ;

KELLEHER, J ;

HEATLEY, RV ;

MASCIETAYLOR, BH ;

BELFIELD, PW .

AGE AND AGEING, 1991, 20 (03) :169-174

[25]

PENSO G, 1982, INDEX PLANTARUM MEDI, P872

[26]

SATORY E, 1988, PHARMACY, V32, P486

[27] PLASMA CHOLESTEROL-LOWERING ACTIVITY OF MONOCYTE COLONY-STIMULATING FACTOR (M-CSF) [J].

SHIMANO, H ;

YAMADA, N ;

MOTOYOSHI, K ;

MATSUMOTO, A ;

ISHIBASHI, S ;

MORI, N ;

TAKAKU, F .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 587 :362-370

[28]

SOMOGYI A, 1987, ALLERGOL IMMUNOPATH, V15, P89

[29]

ZSINKA AJN, 1988, HUNG SCI INSTRUM, V64, P11

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