NADPH-DIAPHORASE REACTIVITY IN ARTICULAR AFFERENTS OF A NORMAL AND INFLAMED KNEE-JOINT IN THE CAT

被引：7

作者：

BSCHEIDL, C ^{[1
]}

HANESCH, U ^{[1
]}

HEPPELMANN, B ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHYSIOL,D-97070 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1994年 / 668卷 / 1-2期

关键词：

NADPH-DIAPHORASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; INFLAMMATION; NOCICEPTION; ARTHRITIS; KNEE JOINT; CAT;

D O I：

10.1016/0006-8993(94)90535-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of NADPH-diaphorase was studied in retrogradely labelled dorsal root ganglion cells innervating the knee joint of the cat. A strong staining reaction was found in 7.5 +/- 1.9% (mean +/- S.D, of 9 normal joints and 6393 labelled perikarya) of the articular afferents. An acute inflammation (32 h) significantly increased this proportion to 10.9 +/- 2.2% (mean +/- S.D. of 5 inflamed joints and 3933 labelled perikarya). The diameter distribution of the somata with a positive NADPH-diaphorase reaction ranged from 18 to 46 mu m with a maximum at 24-28 mu m. These data indicate that a small proportion of knee joint primary afferents may be able to release nitric oxide playing a role in synaptic transmission and in regulatory functions within the peripheral tissue under normal and pathophysiological conditions.

引用

页码：266 / 270

页数：5

共 20 条

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