EXPERIMENTAL-MODEL OF ALLERGIC CONJUNCTIVITIS TO RAGWEED IN GUINEA-PIG

被引：28

作者：

MERAYOLLOVES, J

CALONGE, M

FOSTER, CS

机构：

[1] HARVARD UNIV, SCH MED,MASSACHUSETTS EYE & EAR INFIRM, DEPT OPHTHALMOL,IMMUNOL SERV, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, MASSACHUSETTS EYE & EAR INFIRM, HILLES IMMUNOL LAB, BOSTON, MA 02114 USA

[3] UNIV VALLADOLID, INST OFTALMOBIOL APLICADA, VALLADOLID, SPAIN

来源：

CURRENT EYE RESEARCH | 1995年 / 14卷 / 06期

关键词：

ALLERGY; ATOPY; HAY FEVER CONJUNCTIVITIS; IL-4; RAGWEED; GUINEA PIG;

D O I：

10.3109/02713689509003760

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

An experimental model of ocular allergy was developed in the guinea pig by exposing these animals to ragweed through topical contact on nasal and conjunctival mucosae, followed by subsequent challenge with ragweed contact on the conjunctiva. Animals developed clinical and histological signs of allergy with and without the use of interleukin 4 as adjuvant. This model mimics human hay fever conjunctivitis more naturally than do animal models previously reported, and it may be subsequently more valuable in the study of the response of allergic conjunctivitis to different therapeutic approaches.

引用

页码：487 / 494

页数：8

共 28 条

[21]

MERAYOLLOVES J, 1994, INT CONGR SER, V1068, P107

[22] PROPERTIES OF GUINEA PIG 7S ANTIBODIES .2. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS [J].

OVARY, Z ;

BENACERRAF, B ;

BLOCH, KJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1963, 117 (06) :951-&

[23] AEROSOLIZED ANTIGEN EXPOSURE WITHOUT ADJUVANT CAUSES INCREASED IGE PRODUCTION AND INCREASED AIRWAY RESPONSIVENESS IN THE MOUSE [J].

RENZ, H ;

SMITH, HR ;

HENSON, JE ;

RAY, BS ;

IRVIN, CG ;

GELFAND, EW .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (06) :1127-1138

[24]

Saruya S., 1968, ACTA SOC OPHTHALMOL, V72, P833

[25]

STROCK EM, 1984, ANIMALS MODELS OCULA, P269

[26] DIESEL-EXHAUST PARTICULATES INOCULATED BY THE INTRANASAL ROUTE HAVE AN ADJUVANT ACTIVITY FOR IGE PRODUCTION IN MICE [J].

TAKAFUJI, S ;

SUZUKI, S ;

KOIZUMI, K ;

TADOKORO, K ;

MIYAMOTO, T ;

IKEMORI, R ;

MURANAKA, M .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 79 (04) :639-645

[27] IL-4 INDUCES ALLERGIC-LIKE INFLAMMATORY DISEASE AND ALTERS T-CELL DEVELOPMENT IN TRANSGENIC MICE [J].

TEPPER, RI ;

LEVINSON, DA ;

STANGER, BZ ;

CAMPOSTORRES, J ;

ABBAS, AK ;

LEDER, P .

CELL, 1990, 62 (03) :457-467

[28]

WOODWARD DF, 1986, INVEST OPHTH VIS SCI, V27, P1495

← 1 2 3 →