REACTION OF VAGINAL TISSUE OF RABBITS TO INSERTED SPONGES MADE OF VARIOUS MATERIALS

被引：17

作者：

CHVAPIL, M ^{[1
]}

CHVAPIL, TA ^{[1
]}

OWEN, JA ^{[1
]}

KANTOR, M ^{[1
]}

ULREICH, JB ^{[1
]}

ESKELSON, C ^{[1
]}

机构：

[1] UNIV ARIZONA, HLTH SCI CTR, DEPT SURG, DIV SURG BIOL, TUCSON, AZ 85724 USA

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1979年 / 13卷 / 01期

关键词：

D O I：

10.1002/jbm.820130103

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Sponges of the same size made of collagen (CS), polyurethane (PU), polyvinylalcohol (PVA) and acetylcellulose (AC) were inserted for 10 days in the vaginas of 22 rabbits. Light and scanning electron microscopy of the vaginal wall and its mucosal lining showed signs of cytotoxicity only with PU and AC while CS and PVA picture did not differ from sham controls. In order to explain the reasons for the toxic effects, all sponges were extracted into aqueous or organic solvent media and analyzed by gas liquid chromatography. Only several minute peaks in organic solvents were found. Extracts of all sponges tested for cytotoxicity in fibroblast cultures showed significant inhibition of H3–thymidine uptake. Nevertheless, extract of collagen sponge was significantly less cytotoxic than the extracts of all other sponges. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：1 / 13

页数：13

共 17 条

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