HYPOXIA-SELECTIVE ANTITUMOR AGENTS .2. ELECTRONIC EFFECTS OF 4-SUBSTITUENTS ON THE MECHANISMS OF CYTO-TOXICITY AND METABOLIC STABILITY OF NITRACRINE DERIVATIVES

被引：65

作者：

WILSON, WR

THOMPSON, LH

ANDERSON, RF

DENNY, WA

机构：

[1] UNIV CALIF LAWRENCE LIVERMORE NATL LAB,DIV BIOMED SCI,LIVERMORE,CA 94550

[2] MT VERNON HOSP,CANC RES CAMPAIGN,GRAY LAB,NORTHWOOD HA6 2RN,MIDDX,ENGLAND

[3] UNIV AUCKLAND,SCH MED,CANC RES LAB,AUCKLAND,NEW ZEALAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 01期

关键词：

D O I：

10.1021/jm00121a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：31 / 38

页数：8

共 31 条

[1]

ADAMS GE, 1980, J NATL CANCER I, V64, P555

[2] HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIOTHERAPY AND CHEMOTHERAPY OF CANCER - AN OVERVIEW [J].

ADAMS, GE ;

STRATFORD, IJ .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :71-76

[3]

BUMP EA, 1983, CANCER RES, V43, P997

[4] USE OF MAMMALIAN DNA REPAIR-DEFICIENT MUTANTS TO ASSESS THE EFFECTS OF TOXIC METAL-COMPOUNDS ON DNA [J].

CHRISTIE, NT ;

CANTONI, O ;

EVANS, RM ;

MEYN, RE ;

COSTA, M .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (10) :1661-1670

[5] NITROACRIDINES WITH SELECTIVE TOXICITY TOWARDS HYPOXIC MAMMALIAN-CELLS - SYNTHESIS AND STABILITY OF TRITIATED DERIVATIVES [J].

DENNY, WA ;

CHAMBERS, D ;

STEWART, GM ;

WILSON, WR .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1985, 22 (10) :995-1005

[6] CONSIDERATIONS FOR THE DESIGN OF NITROPHENYL MUSTARDS AS AGENTS WITH SELECTIVE TOXICITY FOR HYPOXIC TUMOR-CELLS [J].

DENNY, WA ;

WILSON, WR .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (06) :879-887

[7] A SEMIAUTOMATED MICROCULTURE METHOD FOR INVESTIGATING GROWTH INHIBITORY EFFECTS OF CYTO-TOXIC COMPOUNDS ON EXPONENTIALLY GROWING CARCINOMA-CELLS [J].

FINLAY, GJ ;

BAGULEY, BC ;

WILSON, WR .

ANALYTICAL BIOCHEMISTRY, 1984, 139 (02) :272-277

[8]

HOY CA, 1985, CANCER RES, V45, P1737

[9] RAPID DETECTION OF DNA-DAMAGING AGENTS USING REPAIR-DEFICIENT CHO CELLS [J].

HOY, CA ;

SALAZAR, EP ;

THOMPSON, LH .

MUTATION RESEARCH, 1984, 130 (05) :321-332

[10] POLY(ADP-RIBOSE) METABOLISM APPEARS NORMAL IN EM9, A MUTAGEN-SENSITIVE MUTANT OF CHO CELLS [J].

IKEJIMA, M ;

BOHANNON, D ;

GILL, DM ;

THOMPSON, LH .

MUTATION RESEARCH, 1984, 128 (02) :213-220

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