CALCITONIN FREE OAT-CELL CARCINOMA OF THE THYROID-GLAND

被引:38
作者
EUSEBI, V
DAMIANI, S
RIVA, C
LLOYD, RV
CAPELLA, C
机构
[1] UNIV PAVIA, DEPT HUMAN PATHOL, VARESE, ITALY
[2] UNIV MICHIGAN HOSP, DEPT PATHOL, ANN ARBOR, MI 48109 USA
关键词
Calcitonin-free small-cell carcinoma; Oat-cell carcinoma; Thyroid;
D O I
10.1007/BF01600144
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Two cases of primary oat-cell carcinoma of thyroid, in a 63-year-old woman and a 73-year-old man, are described. Case 1 was a compound tumour with the oat-cell component merging with a papillary component. Both tumours, in addition to histological features consistent with oat-cell carcinoma, showed immunohistochemical positivity with anti-chromagranin A and anti-synaptophysin antisera. Negative results were obtained when anti-calcitonin and anti-thyroglobulin antisera were employed. Using in situ hybridization, chromogranin A and B messenger RNAs were localized with biotinylated oligonucleotide probes. In contrast, with in situ hybridization, no localization for calcitonin messenger RNA was seen using radioactive and biotinylated probes. It is concluded that these calcitonin-free, small-cell carcinomas should be considered separately from medullary thyroid carcinomas and be regarded as a distinct entity, probably the thyroid equivalent of oat-cell carcinomas of the lung. © 1990 Springer-Verlag.
引用
收藏
页码:267 / 271
页数:5
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