DETERMINATION OF DEGREE OF SUBSTITUTION OF FORMYL GROUPS IN POLYALDEHYDE DEXTRAN BY THE HYDROXYLAMINE HYDROCHLORIDE METHOD

被引：391

作者：

ZHAO, H ^{[1
]}

HEINDEL, ND ^{[1
]}

机构：

[1] LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 03期

关键词：

POLYALDEHYDE DEXTRAN; FORMYL CONTENT; HYDROXYLAMINE TITRATION; DRUG CONJUGATIONS;

D O I：

10.1023/A:1015866104055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Colorimetric or potentiometric titration of the aldehyde residues in polyaldehyde dextran by the hydroxylamine hydrochloride/sodium hydroxide method has been found to be a convenient and accurate method to determine formyl content. Nitrogen combustion analyses on the isolated oximes confirmed the titrametric results.

引用

页码：400 / 402

页数：3

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