机构:Clare Hall Laboratories, Imperial Cancer Research Fund, Potters Bar, EN6 3LD, Herts., Blanche Lane, South Mimms
DIFFLEY, JFX
机构:
[1] Clare Hall Laboratories, Imperial Cancer Research Fund, Potters Bar, EN6 3LD, Herts., Blanche Lane, South Mimms
来源:
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
|
1992年
/
62卷
/
1-2期
关键词:
ARS;
CENTROMERE;
GLOBAL TRANSCRIPTIONAL ACTIVATORS;
TELOMERES;
D O I:
10.1007/BF00584460
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
In the yeast Saccharomyces cerevisiae, several abundant, sequence-specific DNA binding proteins are involved in multiple aspects of chromosome function. In addition to functioning as transcriptional activators of a large number of yeast genes, they are also involved in transcriptional silencing, the initiation of DNA replication, centromere function and regulation of telomere length. This review will consider each of these proteins, focusing on what is known about the mechanisms of their multiple functions.