COCAINE-STIMULUS GENERALIZATION TO 2 NEW DESIGNER DRUGS - METHCATHINONE AND 4-METHYLAMINOREX

被引：40

作者：

YOUNG, R ^{[1
]}

GLENNON, RA ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,SCH PHARM,DEPT MED CHEM,RICHMOND,VA 23298

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 45卷 / 01期

关键词：

COCAINE; CATHINONE; METHCATHINONE; AMINOREX; 4-METHYLAMINOREX;

D O I：

10.1016/0091-3057(93)90110-F

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats were trained to discriminate 8 mg/kg cocaine from saline vehicle for the purpose of examining the stimulus properties of two novel and structurally related drugs of abuse recently confiscated on the illicit market: (+/-)methcathinone and cis(+/-)4-methylaminorex. The stimulus properties of these controlled substance analogs were compared with those of their parent compounds (+/-)cathinone and aminorex, respectively. All agents resulted in cocaine-stimulus generalization with the following rank order of potency: aminorex (ED50 value = 0.8 muM/kg) > methcathinone (1.9 muM/kg) > cathinone (3.7 muM/kg) > 4-methylaminorex (5.2 muM/kg) > cocaine (7.6 muM/kg).

引用

页码：229 / 231

页数：3