MOLECULAR-BIOLOGY OF THE RENIN-ANGIOTENSIN SYSTEM

被引：331

作者：

GRIENDLING, KK

MURPHY, TJ

ALEXANDER, RW

机构：

[1] Division of Cardiology, Emory University, Atlanta, GA 30322, P.O. Box LL

来源：

CIRCULATION | 1993年 / 87卷 / 06期

关键词：

RESEARCH ADVANCES SERIES; RENIN; ANGIOTENSIN;

D O I：

10.1161/01.CIR.87.6.1816

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in molecular biology of the renin-angiotensin system have expanded our understanding of the basic biochemistry and physiology of this important hormonal system. The genetic and protein sequences are available for each of its components. Current research is directed toward examining the regulation of expression and activity of these molecules as well as the existence and functionality of local renin-angiotensin systems. The possible association of genetic polymorphisms in any one component with vascular and cardiac disease also is under investigation. Ultimately, such studies may provide the basis for new therapeutic strategies.

引用

页码：1816 / 1828

页数：13

共 120 条

[1] METABOLISM AND PRODUCTION OF ANGIOTENSIN-I IN DIFFERENT VASCULAR BEDS IN SUBJECTS WITH HYPERTENSION [J].