IGF-I ALTERS ENERGY-EXPENDITURE AND PROTEIN-METABOLISM DURING PARENTERAL-FEEDING IN RATS

被引：15

作者：

LING, PR ^{[1
]}

GOLLAHER, C ^{[1
]}

COLON, E ^{[1
]}

ISTFAN, N ^{[1
]}

BISTRIAN, BR ^{[1
]}

机构：

[1] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,NUTR INFECT LAB,BOSTON,MA 02215

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 61卷 / 01期

关键词：

INSULIN-LIKE GROWTH FACTOR I(IGF-I); FASTING STATE; FED STATE; PROTEIN METABOLISM; GLUCOSE METABOLISM; ENERGY EXPENDITURE;

D O I：

10.1093/ajcn/61.1.116

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In this study, 20 mu g.kg(-1).h(-1) of recombinant human insulin-like growth factor I (IGF-I) was infused into normal healthy rats to examine the effects of IGF-I on glucose, protein, and energy metabolism in either overnight-fasting or parenteral-feeding states. The fed state was maintained by continuous intravenous feeding of a complete diet containing 838 kJ.kg(-1).d(-1), 2 g N.kg(-1).d(-1), and no fat. At each nutritional state, one-half of the animals received IGF-I infusion while the other half received saline as control. [C-14-1]leucine and [H-3-6]glucose were used to determine the effects of IGF-I on protein and glucose kinetics during fed and fasting states. The results showed that 1) infusion of IGF-I at this amount did not alter plasma glucose appearance and only marginally decreased plasma glucose concentrations in both nutritional states; 2) during fasting, IGF-I did not show anabolic effects on protein metabolism either at the whole-body level or in individual tissues. However, during feeding, IGF-I significantly stimulated exogenous nitrogen utilization by the whole body; and 3) IGF-I reduced the thermogenic effect of feeding. The results suggest that parenteral feeding may be an important variable in the response of protein anabolism to IGF-I in vivo.

引用

页码：116 / 120

页数：5

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