IGF-I ALTERS ENERGY-EXPENDITURE AND PROTEIN-METABOLISM DURING PARENTERAL-FEEDING IN RATS

被引：15

作者：

LING, PR ^{[1
]}

GOLLAHER, C ^{[1
]}

COLON, E ^{[1
]}

ISTFAN, N ^{[1
]}

BISTRIAN, BR ^{[1
]}

机构：

[1] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,NUTR INFECT LAB,BOSTON,MA 02215

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 61卷 / 01期

关键词：

INSULIN-LIKE GROWTH FACTOR I(IGF-I); FASTING STATE; FED STATE; PROTEIN METABOLISM; GLUCOSE METABOLISM; ENERGY EXPENDITURE;

D O I：

10.1093/ajcn/61.1.116

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In this study, 20 mu g.kg(-1).h(-1) of recombinant human insulin-like growth factor I (IGF-I) was infused into normal healthy rats to examine the effects of IGF-I on glucose, protein, and energy metabolism in either overnight-fasting or parenteral-feeding states. The fed state was maintained by continuous intravenous feeding of a complete diet containing 838 kJ.kg(-1).d(-1), 2 g N.kg(-1).d(-1), and no fat. At each nutritional state, one-half of the animals received IGF-I infusion while the other half received saline as control. [C-14-1]leucine and [H-3-6]glucose were used to determine the effects of IGF-I on protein and glucose kinetics during fed and fasting states. The results showed that 1) infusion of IGF-I at this amount did not alter plasma glucose appearance and only marginally decreased plasma glucose concentrations in both nutritional states; 2) during fasting, IGF-I did not show anabolic effects on protein metabolism either at the whole-body level or in individual tissues. However, during feeding, IGF-I significantly stimulated exogenous nitrogen utilization by the whole body; and 3) IGF-I reduced the thermogenic effect of feeding. The results suggest that parenteral feeding may be an important variable in the response of protein anabolism to IGF-I in vivo.

引用

页码：116 / 120

页数：5

共 30 条

[21]

Zapf J., Schmif C., Froesch E.R., Biological and immunological properties of insulin-like growth factors (IGF) I and II, Clin Endocrinol Metab, 13, pp. 3-30, (1984)

[22]

Lieberman S.A., Bukar J., Chen S.A., Et al., Effects of recombinant human insulin-like growth factor-I (rhIGF-I) on total and free IGF-I concentrations, IGF-binding protein, and glycemic response in humans, J Clin Endocrinol Metab, 75, pp. 30-36, (1992)

[23]

Clemmons D.R., Klibanski A., Underwood L.E., Et al., Reduction of plasma immunoreactive somatomedin C during fasting in humans, J Clin Endocrinol Metab, 53, pp. 1247-1250, (1981)

[24]

Donahue S.P., Phillips L.S., Response of IGF-I to nutritional support in malnourished hospital patients: A possible indicator of short-term changes in nutritional status, Am J Clin Nutr, 50, pp. 962-969, (1989)

[25]

Bar R.S., Boes M., Clemmons D.R., Et al., Insulin differentially alters transcapillary movement of intravascular IGFBP-1, IGFBP-2, and endothelial cell IGF-binding proteins in the rat heart, Endocrinology, 127, pp. 497-499, (1990)

[26]

Clemmons D.R., Insulin-like growth factor binding proteins, Insulin-like Growth Factor: Molecular and Cellular Aspects, pp. 49-85, (1991)

[27]

Clemmons D.R., Underwood L.E., Nutritional regulation of IGF-I and IGF binding proteins, Annu Rev Nutr, 11, pp. 393-412, (1991)

[28]

Sinha M.K., Buchanan C., Leggett N., Et al., Mechanism of IGF-I-stimulated glucose transport in human adipocytes: Demonstration of specific IGF-I receptor not involved in stimulation of glucose transport, Diabetes, 38, pp. 1217-1225, (1989)

[29]

Mauras N., Horber F.F., Haymond M.W., Low dose recombinant human insulin-like growth factor-I fails to affect protein anabolism but inhibits islet cell secretion in humans, J Clin Endocrinol Metab, 75, pp. 1192-1197, (1992)

[30]

Flatt J.P., Energy cost of ATP synthesis, Energy Metabolism, Tissue Determinations and Cellular Corollaries, pp. 319-341, (1992)

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