SOFTENING OF SEMISYNTHETIC SUPPOSITORY BASES

被引：5

作者：

FABREGAS, JL

机构：

[1] Research Institute, Laboratories Almirall, Barcelona, SA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 08期

关键词：

D O I：

10.3109/03639049109043846

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The melting process of seventeen semisynthetic suppository bases has been evaluated by using a classical open capillary method together with differential scanning calorimetry and rheological analysis, in order to establish a physical mechanism for their premature softening. The presence in these materials of a mixture of different fat components with divergent melting points, as detected by the presented methods, satisfactorily explains this phenomenon.

引用

页码：1083 / 1096

页数：14

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