CELLULAR AGING RELATED PROTEINS SECRETED BY HUMAN FIBROBLASTS

被引：16

作者：

ELEFTHERIOU, CS

TRAKAS, NB

TZARTOS, SJ

机构：

[1] Hellenic Pasteur Institute, Athens

来源：

MUTATION RESEARCH | 1991年 / 256卷 / 2-6期

关键词：

CELLULAR AGING; FIBROBLASTS; SECRETED PROTEINS; EXTRACELLULAR MATRIX;

D O I：

10.1016/0921-8734(91)90006-W

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Fibroblast secreted proteins participate in the formation of extracellular matrix. Extracellular matrix affects growth factor action, mediates cell adhesion and supports cell growth. Structural and quantitative characteristics of secreted proteins are modified in a similar manner, during both in vivo and in vitro cellular ageing. Such ageing related modifications may either be directly controlled by primary ageing causes, or evolve from a reformation of the extracellular matrix induced by a few ageing defects in key proteins such as fibronectin. They may result in the further inhibition of cell adhesion, cell stimulation by growth factors and, eventually, of cell proliferative ability.

引用

页码：127 / 138

页数：12

共 91 条

[41] THE SMALL DERMATAN SULFATE PROTEOGLYCANS SYNTHESIZED BY FIBROBLASTS DERIVED FROM SKIN, SYNOVIUM AND GINGIVA SHOW TISSUE-RELATED HETEROGENEITY [J].