MELANOGENESIS AS A TARGETING STRATEGY AGAINST METASTATIC MELANOMA - A REASSESSMENT

被引:38
作者
PROTA, G
DISCHIA, M
MASCAGNA, D
机构
[1] Department of Organic and Biological Chemistry, University of Naples Federico II, Naples, 180134
关键词
MELANIN PRECURSORS; MELANOMA CHEMOTHERAPY; PHENOLIC MELANOCYTOTOXIC AGENTS; QUINONES; TARGETING STRATEGIES; TYROSINASE;
D O I
10.1097/00008390-199412000-00002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Following the early study of Hochstein and Cohen in 1963 suggesting the potential toxicity of quinonoid melanin precursors, considerable interest has been focused on the possibility of exploiting the pigment-producing pathway as a targeting strategy against metastatic melanoma. Several melanocytotoxic phenolic pro-drugs have been developed, and some of them have reached the preclinical stage. Here we review the progress made so far and supply some insight into the chemical and biochemical mechanisms underlying the melanocytotoxic response.
引用
收藏
页码:351 / 358
页数:8
相关论文
共 81 条
[1]  
Rumke P., Dewit L., Non surgical treatment of melanoma, Cutaneous Melanoma. Current Status of Knowledge Andfuture Perspectives, pp. 63-98, (1987)
[2]  
Joensuu H., Association between chemotherapy response and rate of disease progression in disseminated melanoma, Br J Cancer, 63, pp. 154-156, (1991)
[3]  
Sheridan E., Hancock B.W., Systemic treatment of metastatic malignant melanoma, Diagnosis and Management of Melanoma in Clinical Practic, pp. 135-156, (1992)
[4]  
Garbe C., Chemotherapy and chemoimmunotherapy in disseminated malignant melanoma, Melanoma Res, 3, pp. 291-299, (1993)
[5]  
Riley P.A., Progress and prospects for therapeutic targeting strategies for disseminated melanoma, Diagnosis and Management of Melanoma in Clinical Practice, pp. 157-172, (1992)
[6]  
Prota G., Melanins and Melanogenesis, (1992)
[7]  
Aroca P., Garcia-Borron J.C., Solano F., Et al., Regulation of distal mammalian melanogenesis I. Partial purification and characterization of a dopachrome converting factor: Dopachrome tautomerase, Biochim Biophys Acta, 1035, pp. 266-275, (1990)
[8]  
Pawelek J., After dopachrome?, Pigment Cell Res, 4, pp. 53-62, (1991)
[9]  
Townsend D., Oetting W.S., Polman T., Et al., Purification and characterization of dopachrome tautomerase (DT), Pigment Cell Res, pp. 32-35, (1992)
[10]  
Palumbo A., D'ischia M., Misuraca G., Et al., Effect of metal ions on the rearrangement of dopachrome, Biochim Biophys Acta, 925, pp. 203-209, (1987)