MELANOGENESIS AS A TARGETING STRATEGY AGAINST METASTATIC MELANOMA - A REASSESSMENT

被引：38

作者：

PROTA, G

DISCHIA, M

MASCAGNA, D

机构：

[1] Department of Organic and Biological Chemistry, University of Naples Federico II, Naples, 180134

来源：

MELANOMA RESEARCH | 1994年 / 4卷 / 06期

关键词：

MELANIN PRECURSORS; MELANOMA CHEMOTHERAPY; PHENOLIC MELANOCYTOTOXIC AGENTS; QUINONES; TARGETING STRATEGIES; TYROSINASE;

D O I：

10.1097/00008390-199412000-00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following the early study of Hochstein and Cohen in 1963 suggesting the potential toxicity of quinonoid melanin precursors, considerable interest has been focused on the possibility of exploiting the pigment-producing pathway as a targeting strategy against metastatic melanoma. Several melanocytotoxic phenolic pro-drugs have been developed, and some of them have reached the preclinical stage. Here we review the progress made so far and supply some insight into the chemical and biochemical mechanisms underlying the melanocytotoxic response.

引用

页码：351 / 358

页数：8

共 81 条

[31]

Riley P.A., Hydroxyanisole: The current status, Hydroxyanisole: Recent Advance in Antimelanoma Therapy, pp. 1-10, (1984)

[32]

Dewey D.L., Holden J.L., Perturbations in the cell cycle caused by 4-hydroxyanisole, Hydroxyanisole: Recent Advances in Antimelanoma Therapy, pp. 143-151, (1984)

[33]

Morgan B.D.G., Recent results of a clinical pilot study of intraarterial 4-HA chemotherapy of malignant melanoma, Hydroxyanisole: Recent Advances In Antimelanoma Therapy, pp. 233-241, (1984)

[34]

Schwabe K., Fichtner I., Tschiersch B., Non-selective action of 4-hydroxyanisole on melanoma cells in vivo, Pigment Cell Res, 3, pp. 8-10, (1990)

[35]

Naish-Byfield S., Cooksey C.J., Latter A.M., Et al., In vitro assessment of the structure-activity relationship of tyrosinase-dependent cytotoxicity of a series of substituted phenols, Melanoma Res, 1, pp. 273-288, (1991)

[36]

Smit N.P.M., Peters K., Menko W., Et al., Cytotoxicity of a selected series of substituted phenols towards cultured melanoma cells, Melanoma Res, 2, pp. 295-304, (1992)

[37]

Lerner A.B., Fitzpatrick T.B., Biochemistry of melanin formation, Physiol Rev, 30, pp. 91-126, (1950)

[38]

Jimbow K., Obata H., Pathak M.A., Et al., Mechanism of depigmentation by hydroquinone, J Invest Dermatol, 62, pp. 436-449, (1974)

[39]

Hashimoto A., Ichihashi M., Mishima Y., The mechanism of depigmentation by hydroquinone, a study on suppression and recovery process of tyrosinase activity in pigment cells in vivo and in vitro, Jpn J Dermatol, 94, pp. 797-804, (1984)

[40]

Penney K.B., Smith C.J., Allen J.C., Depigmenting action of hydroquinone depends on disruption of fundamental cell processes, J Invest Dermatol, 82, pp. 308-310, (1984)

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