NUCLEOSIDES AND NUCLEOTIDES .127. A NOVEL AND CONVENIENT POST-SYNTHETIC MODIFICATION METHOD FOR THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CARRYING AMINO LINKERS AT THE 5-POSITION OF 2'-DEOXYURIDINE

被引：41

作者：

ONO, A ^{[1
]}

HAGINOYA, N ^{[1
]}

KIYOKAWA, M ^{[1
]}

MINAKAWA, N ^{[1
]}

MATSUDA, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

NUCLEOSIDE; 5-METHOXYCARBONYL-2'-DEOXYURIDINE; OLIGODEOXYRIBONUCLEOTIDE; AMINO LINKER; POST-SYNTHETIC MODIFICATION;

D O I：

10.1016/S0960-894X(01)80145-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-Methoxycarbonyl-2'-deoxyuridine has been synthesized and incorporated in oligonucleotides. The fully protected oligonucleotides were treated with diaminoethane or diaminohexane and the oligonucleotides were deprotected and purified to give oligonucleotides carrying amino-linkers, which were further derivatized with an intercalator. Properties of these oligonucleotides are described.

引用

页码：361 / 366

页数：6

共 14 条

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