CONJUGATED ADDITION OF PRIMARY AMINES TO ALPHA-(1-HYDROXYALKYL)ACRYLIC COMPOUNDS - NOVEL SYNTHESIS OF POLYFUNCTIONAL BETA-LACTAMS AND GAMMA-LACTAMS

被引：17

作者：

BENAYED, T ^{[1
]}

AMRI, H ^{[1
]}

ELGAIED, MM ^{[1
]}

VILLERAS, J ^{[1
]}

机构：

[1] FAC SCI & TECH NANTES,SYNTH ORGAN LAB,CNRS,URA 475,F-44072 NANTES,FRANCE

来源：

TETRAHEDRON | 1995年 / 51卷 / 35期

关键词：

AMINES; ETHYL ALPHA-(1-HYDROXYALKYL)ACRYLALES; CONJUGATED ADDITION; ALPHA-(1-HYDROXYALKYL)AZETIDIN-2-ONES; ALPHA-ALKYLIDENEAZETIDIN-2-ONES; ALPHA; BETA-DIFUNCTIONALIZED GAMMA-BUTYROLACTAMES; PERHYDRO-1,2-PYRIDAZINONES;

D O I：

10.1016/0040-4020(95)00538-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct condensation, in methanol, of primary amines on ethyl-alpha-(1-hydroxyalkyl)acrylates and 2-(1-carbethoxy-1-hydroxyethyl)acrylonitrile yielded respectively to alpha-(1-hydroxyalkyl)-beta-lactames and alpha,beta-difunctionalized gamma-lactames in good to fair yields. In the latter case, reaction with N,N-dialkylated hydrazines gave perhydro-1,2-pyridazinones.

引用

页码：9633 / 9642

页数：10

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