EFFICIENT DETERMINATION OF THE PKA VALUES OF 6 CHLORINATED PHENOLS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY

被引：29

作者：

CHAMINADE, P ^{[1
]}

BAILLET, A ^{[1
]}

FERRIER, D ^{[1
]}

BOURGUIGNON, B ^{[1
]}

MASSART, DL ^{[1
]}

机构：

[1] DIENST FARMACEUT BIOMED ANAL,INST FARMACEUT,FAK GENEESKUNDE FARM,B-1090 BRUSSELS,BELGIUM

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 280卷 / 01期

关键词：

LIQUID CHROMATOGRAPHY; ACIDITY CONSTANTS; CHLOROPHENOLS; MOBILE PHASE OPTIMIZATION;

D O I：

10.1016/0003-2670(93)80246-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A non-linear regression algorithm is used to compute acidity constants from capacity factors recorded at various pH values using a standard reversed-phase column and acetonitrile as organic modifier. An application is presented for six chlorophenols and the pK(a) values calculated for those compounds compare favourably with literature data obtained by other methods in aqueous media. This pK(a) determination method is also suitable for mobile phase optimization; a resolution map based on pK(a) values from the literature and liquid chromatography-related pK(a) values is presented.

引用

页码：93 / 101

页数：9

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