ENANTIOSELECTIVE, MULTIGRAM-SCALE SYNTHESIS WITH A CATALYTIC ANTIBODY

被引:61
作者
REYMOND, JL
REBER, JL
LERNER, RA
机构
[1] Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, 92037
[2] Sandoz Pharma, Chemical Process R + D, Basel
来源
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 04期
关键词
D O I
10.1002/anie.199404751
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The enantioselective conversion of the achiral enol ether 1 into the chiral ketone 2 was carried out on a multigram‐scale with a monoclonal antibody (Ab). This procedure requires only conventional laboratory equipment. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码:475 / 477
页数:3
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