ANTIBODY CATALYSIS OF GLYCOSIDIC BOND HYDROLYSIS

被引：68

作者：

REYMOND, JL

JANDA, KD

LERNER, RA

机构：

[1] SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

[2] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 12期

关键词：

D O I：

10.1002/anie.199117111

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the preparation of abzymes with glycolytic activity, the generation of an antibody that catalyzes the hydrolysis of acetal 1 represents a first step. The antibody (or abzyme) is obtained from immunization with piperidinium hapten 2. A key factor in promoting catalysis is probably the proper placement of the leaving group in 1 as axial substituent. (Figure Presented.) Copyright © 1991 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1711 / 1713

页数：3

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