REQUIREMENT OF HEPARAN-SULFATE FOR BFGF-MEDIATED FIBROBLAST GROWTH AND MYOBLAST DIFFERENTIATION

被引：1418

作者：

RAPRAEGER, AC ^{[1
]}

KRUFKA, A ^{[1
]}

OLWIN, BB ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

SCIENCE | 1991年 / 252卷 / 5013期

关键词：

D O I：

10.1126/science.1646484

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.

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页码：1705 / 1708

页数：4

相关论文

共 39 条

[1] BASIC FIBROBLAST GROWTH-FACTOR BINDS TO SUBENDOTHELIAL EXTRACELLULAR-MATRIX AND IS RELEASED BY HEPARITINASE AND HEPARIN-LIKE MOLECULES [J].

BASHKIN, P ;

DOCTROW, S ;

KLAGSBRUN, M ;

SVAHN, CM ;

FOLKMAN, J ;

VLODAVSKY, I .

BIOCHEMISTRY, 1989, 28 (04) :1737-1743

[2] THE HEPARIN-BINDING (FIBROBLAST) GROWTH-FACTOR FAMILY OF PROTEINS [J].

BURGESS, WH ;

MACIAG, T .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :575-606

[3]

BURRUS LW, 1989, J BIOL CHEM, V264, P18647

[4] HUMAN EPIDERMAL GROWTH-FACTOR AND PROLIFERATION OF HUMAN FIBROBLASTS [J].

CARPENTER, G ;

COHEN, S .

JOURNAL OF CELLULAR PHYSIOLOGY, 1976, 88 (02) :227-237

[5] GROWTH-FACTOR CONTROL OF SKELETAL-MUSCLE DIFFERENTIATION - COMMITMENT TO TERMINAL DIFFERENTIATION OCCURS IN G1 PHASE AND IS REPRESSED BY FIBROBLAST GROWTH-FACTOR [J].

CLEGG, CH ;

LINKHART, TA ;

OLWIN, BB ;

HAUSCHKA, SD .

JOURNAL OF CELL BIOLOGY, 1987, 105 (02) :949-956

[6]

COUGHLIN SR, 1988, J BIOL CHEM, V263, P988

[7] CLONING AND EXPRESSION OF 2 DISTINCT HIGH-AFFINITY RECEPTORS CROSS-REACTING WITH ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].

DIONNE, CA ;

CRUMLEY, G ;

BELLOT, F ;

KAPLOW, JM ;

SEARFOSS, G ;

RUTA, M ;

BURGESS, WH ;

JAYE, M ;

SCHLESSINGER, J .

EMBO JOURNAL, 1990, 9 (09) :2685-2692

[8] ATP SULFURYLASE FROM PENCILLIUM-CHRYSOGENUM .4. ADENOSINE-TRIPHOSPHATE SULFURYLASE FROM PENICILLIUM-CHRYSOGENUM - EQUILIBRIUM BINDING, SUBSTRATE HYDROLYSIS, AND ISOTOPE EXCHANGE STUDIES [J].

FARLEY, JR ;

NAKAYAMA, G ;

CRYNS, D ;

SEGEL, IH .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 185 (02) :376-390

[9] HUMAN KGF IS FGF-RELATED WITH PROPERTIES OF A PARACRINE EFFECTOR OF EPITHELIAL-CELL GROWTH [J].

FINCH, PW ;

RUBIN, JS ;

MIKI, T ;

RON, D ;

AARONSON, SA .

SCIENCE, 1989, 245 (4919) :752-755

[10] ROLE OF EXTRACELLULAR-MATRIX IN THE ACTION OF BASIC FIBROBLAST GROWTH-FACTOR - MATRIX AS A SOURCE OF GROWTH-FACTOR FOR LONG-TERM STIMULATION OF PLASMINOGEN-ACTIVATOR PRODUCTION AND DNA-SYNTHESIS [J].

FLAUMENHAFT, R ;

MOSCATELLI, D ;

SAKSELA, O ;

RIFKIN, DB .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 140 (01) :75-81

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