REQUIREMENT OF HEPARAN-SULFATE FOR BFGF-MEDIATED FIBROBLAST GROWTH AND MYOBLAST DIFFERENTIATION

被引：1418

作者：

RAPRAEGER, AC ^{[1
]}

KRUFKA, A ^{[1
]}

OLWIN, BB ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

SCIENCE | 1991年 / 252卷 / 5013期

关键词：

D O I：

10.1126/science.1646484

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.

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页码：1705 / 1708

页数：4

相关论文

共 39 条

[21] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[22] PURIFICATION AND COMPLEMENTARY-DNA CLONING OF A RECEPTOR FOR BASIC FIBROBLAST GROWTH-FACTOR [J].

LEE, PL ;

JOHNSON, DE ;

COUSENS, LS ;

FRIED, VA ;

WILLIAMS, LT .

SCIENCE, 1989, 245 (4913) :57-60

[23] EXAMINATION OF THE SUBSTRATE-SPECIFICITY OF HEPARIN AND HEPARAN-SULFATE LYASES [J].

LINHARDT, RJ ;

TURNBULL, JE ;

WANG, HM ;

LOGANATHAN, D ;

GALLAGHER, JT .

BIOCHEMISTRY, 1990, 29 (10) :2611-2617

[24]

LORIES V, 1989, J BIOL CHEM, V264, P7009

[25] A MURINE FIBROBLAST GROWTH-FACTOR (FGF) RECEPTOR EXPRESSED IN CHO CELLS IS ACTIVATED BY BASIC FGF AND KAPOSI FGF [J].

MANSUKHANI, A ;

MOSCATELLI, D ;

TALARICO, D ;

LEVYTSKA, V ;

BASILICO, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4378-4382

[26] HIGH AND LOW AFFINITY BINDING-SITES FOR BASIC FIBROBLAST GROWTH-FACTOR ON CULTURED-CELLS - ABSENCE OF A ROLE FOR LOW AFFINITY BINDING IN THE STIMULATION OF PLASMINOGEN-ACTIVATOR PRODUCTION BY BOVINE CAPILLARY ENDOTHELIAL-CELLS [J].

MOSCATELLI, D .

JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 131 (01) :123-130

[27]

NEUFELD G, 1986, J BIOL CHEM, V261, P5631

[28] IDENTIFICATION OF THE FIBROBLAST GROWTH-FACTOR RECEPTOR OF SWISS-3T3 CELLS AND MOUSE SKELETAL-MUSCLE MYOBLASTS [J].

OLWIN, BB ;

HAUSCHKA, SD .

BIOCHEMISTRY, 1986, 25 (12) :3487-3492

[29]

OLWIN BB, UNPUB

[30] A DISTINCTIVE FAMILY OF EMBRYONIC PROTEIN-TYROSINE KINASE RECEPTORS [J].

PASQUALE, EB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5812-5816

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