EFFECT OF ORAL-ADMINISTRATION OF BACTERIAL EXTRACTS ON THE BACTERICIDAL CAPACITY OF POLYMORPHONUCLEAR LEUKOCYTES IN CHILDREN WITH RECURRENT RESPIRATORY-INFECTIONS

被引：6

作者：

KANTAR, A ^{[1
]}

OGGIANO, N ^{[1
]}

ROMAGNONI, GG ^{[1
]}

GIORGI, PL ^{[1
]}

机构：

[1] SIMES SPA,MED DIRECT,BRESSO,ITALY

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1991年 / 19卷 / 06期

关键词：

BACTERIAL EXTRACTS; RESPIRATORY INFECTIONS; POLYMORPHONUCLEAR LEUKOCYTES; BACTERICIDAL CAPACITY; CHEMILUMINESCENCE;

D O I：

10.1177/030006059101900604

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of orally administered bacterial extracts given intermittently over 16 weeks on the bactericidal capacity of polymorphonuclear leucocytes (PMNs) in children with recurrent respiratory infections was investigated using a luminol-amplified chemiluminescence assay. Chemiluminescence of PMNs stimulated with zymosan or N-formyl-methionyl-leucyl-phenylalanine (fMLP) before and after treatment with bacterial extracts or intramuscular benzanthine penicillin was evaluated. Chemiluminescence induced by opsonized zymosan increased significantly (P < 0.05) after treatment with bacterial extracts, whereas no significant changes were observed in the fMLP-stimulated PMNs. Long-acting penicillin treatment did not significantly affect zymosan- or fMLP-stimulated chemiluminescence. The data suggest that orally administered bacterial extracts can increase the opsonic capacity of serum and thus the bactericidal capacity of PMNs in subjects with recurrent respiratory infections.

引用

页码：451 / 456

页数：6