ERROR FILTRATION, INTERFERENCE, AND THE HUMAN LINKAGE MAP

被引：63

作者：

SHIELDS, DC

COLLINS, A

BUETOW, KH

MORTON, NE

机构：

[1] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,DEPT COMMUNITY MED,CANC RES CAMPAIGN,SOUTHAMPTON S09 4XY,ENGLAND

[2] FOX CHASE CANC INST,DIV POPULAT SCI,PHILADELPHIA,PA 19111

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 15期

关键词：

GENETIC LINKAGE; GENE MAP; HUMAN GENOME;

D O I：

10.1073/pnas.88.15.6501

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

引用

页码：6501 / 6505

页数：5

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