EFFECTS OF CA2+ ANTAGONISTS AND AMINOGLYCOSIDE ANTIBIOTICS ON CA2+ CURRENT IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA

被引：32

作者：

NAKAGAWA, T

KAKEHATA, S

AKAIKE, N

KOMUNE, S

TAKASAKA, T

UEMURA, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL,SENDAI,MIYAGI 980,JAPAN

[2] KYUSHU UNIV,FAC MED,DEPT OTORHINOLARYNGOL,FUKUOKA 812,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 580卷 / 1-2期

关键词：

WHOLE-CELL VOLTAGE CLAMP; CALCIUM CHANNEL; OUTER HAIR CELL; GUINEA PIG; CA2+ ANTAGONIST; AMINOGLYCOSIDE ANTIBIOTIC;

D O I：

10.1016/0006-8993(92)90966-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ >> Cd2+ >> Ni2+ > Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > omega-conotoxin > methoxyverapamil = diltiazem >> amiloride for organic ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.

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页码：345 / 347

页数：3

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