EFFECTS OF CA2+ ANTAGONISTS AND AMINOGLYCOSIDE ANTIBIOTICS ON CA2+ CURRENT IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA

被引：32

作者：

NAKAGAWA, T

KAKEHATA, S

AKAIKE, N

KOMUNE, S

TAKASAKA, T

UEMURA, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL,SENDAI,MIYAGI 980,JAPAN

[2] KYUSHU UNIV,FAC MED,DEPT OTORHINOLARYNGOL,FUKUOKA 812,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 580卷 / 1-2期

关键词：

WHOLE-CELL VOLTAGE CLAMP; CALCIUM CHANNEL; OUTER HAIR CELL; GUINEA PIG; CA2+ ANTAGONIST; AMINOGLYCOSIDE ANTIBIOTIC;

D O I：

10.1016/0006-8993(92)90966-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ >> Cd2+ >> Ni2+ > Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > omega-conotoxin > methoxyverapamil = diltiazem >> amiloride for organic ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.

引用

收藏

页码：345 / 347

页数：3

相关论文

共 24 条

[11] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES [J].

HAMILL, OP ;

MARTY, A ;

NEHER, E ;

SAKMANN, B ;

SIGWORTH, FJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02) :85-100

[12]

HAWKINS J. E., 1959, ANN OTOL RHINOL AND LARYNGOL, V68, P698

[13] BLOCKAGE OF THE TRANSDUCTION CHANNELS OF HAIR-CELLS IN THE BULLFROGS SACCULUS BY AMINOGLYCOSIDE ANTIBIOTICS [J].

KROESE, ABA ;

DAS, A ;

HUDSPETH, AJ .

HEARING RESEARCH, 1989, 37 (03) :203-217

[14] FUNCTIONAL-ROLE OF THE OLIVOCOCHLEAR BUNDLE - A MOTOR UNIT CONTROL-SYSTEM IN THE MAMMALIAN COCHLEA [J].

LEPAGE, EL .

HEARING RESEARCH, 1989, 38 (03) :177-198

[15] EXCITATORY AND INHIBITORY AMINO-ACIDS AND PEPTIDE-INDUCED RESPONSES IN ACUTELY ISOLATED RAT SPINAL DORSAL HORN NEURONS [J].

MURASE, K ;

RYU, PD ;

RANDIC, M .

NEUROSCIENCE LETTERS, 1989, 103 (01) :56-63

[16] ATP-INDUCED CURRENT IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA [J].

NAKAGAWA, T ;

AKAIKE, N ;

KIMITSUKI, T ;

KOMUNE, S ;

ARIMA, T .

JOURNAL OF NEUROPHYSIOLOGY, 1990, 63 (05) :1068-1074

[17] CALCIUM-CHANNEL IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA [J].

NAKAGAWA, T ;

KAKEHATA, S ;

AKAIKE, N ;

KOMUNE, S ;

TAKASAKA, T ;

UEMURA, T .

NEUROSCIENCE LETTERS, 1991, 125 (01) :81-84

[18] EXCITATORY AMINO-ACID RESPONSE IN ISOLATED NUCLEUS TRACTUS SOLITARII NEURONS OF THE RAT [J].

NAKAGAWA, T ;

SHIRASAKI, T ;

WAKAMORI, M ;

FUKUDA, A ;

AKAIKE, N .

NEUROSCIENCE RESEARCH, 1990, 8 (02) :114-123

[19]

NARAHASHI T, 1987, J PHYSIOL-LONDON, V383, P231

[20] MECHANO-ELECTRICAL TRANSDUCTION CURRENTS IN ISOLATED VESTIBULAR HAIR-CELLS OF THE CHICK [J].

OHMORI, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1985, 359 (FEB) :189-&