COMPARATIVE EFFECTS OF A HIGHLY SPECIFIC PROTEIN-KINASE-C INHIBITOR, CALPHOSTIN-C AND CALMODULIN INHIBITORS ON ANGIOTENSIN-STIMULATED ALDOSTERONE SECRETION

被引：4

作者：

GANGULY, A ^{[1
]}

WALDRON, C ^{[1
]}

机构：

[1] JAMES A HALEY VET HOSP,TAMPA,FL 33612

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1994年 / 50卷 / 5-6期

关键词：

D O I：

10.1016/0960-0760(94)90129-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the relative roles of the calcium-calmodulin system and protein kinase C in angiotensin-mediated aldosterole secretion. We used a highly specific protein kinase C inhibitor, calphostin C and two well-accepted calmodulin inhibitors, W-7 and calmidazolium. Although both types of inhibitors affected angiotensin-induced aldosterone secretion, as judged by the inhibitory doses of these compounds, angiotensin-evoked aldosterone secretion was more sensitive to calmodulin inhibition than protein kinase C inhibition. Manipulation of intracellular calcium by dantrolene and thapsigargin also modified aldosterone secretion significantly.

引用

页码：253 / 260

页数：8

共 30 条

[1] PARTICIPATION OF VOLTAGE-DEPENDENT CALCIUM CHANNELS IN THE REGULATION OF ADRENAL GLOMERULOSA FUNCTION BY ANGIOTENSIN-II AND POTASSIUM [J].