SEROLOGIC EVALUATION OF PATIENTS RECEIVING PROCAINAMIDE

被引：37

作者：

MONGEY, AB

DONOVANBRAND, R

THOMAS, TJ

ADAMS, LE

HESS, EV

机构：

[1] UNIV CINCINNATI,MED CTR,DEPT MED,DIV IMMUNOL,MAIL LOCAT 563,231 BETHESDA AVE,CINCINNATI,OH 45267

[2] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MED,DIV RHEUMATOL,NEW BRUNSWICK,NJ 08903

来源：

ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 02期

关键词：

D O I：

10.1002/art.1780350216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This controlled study examined the characteristics of serologic abnormalities in 52 patients receiving procainamide for cardiac arrhythmias, who had no symptoms of a connective tissue disease. Antinuclear antibodies occurred in 43 patients (83%). Significant elevation of antibody binding to single-stranded DNA (mean +/- SEM 30 +/- 2.6%), double-stranded DNA (13 +/- 1.1%), Z-DNA (optical density 0.54 +/- 0.06), and poly A (7.2 +/- 0.6%) was seen (P < 0.001). Thirty-four patients (65.4%) had antibodies to total histones, most frequently, the H2A/2B dimer. IgG antibodies to H2A/2B correlated with the cumulative procainamide dose. One patient subsequently developed drug-related lupus.

引用

页码：219 / 223

页数：5

共 14 条

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