2 METHYL-ESTER DERIVATIVES OF MICROCYSTINS, CYCLIC HEPTAPEPTIDE HEPATOTOXINS, ISOLATED FROM ANABAENA-FLOS-AQUAE STRAIN CYA 83/1

被引：49

作者：

SIVONEN, K

SKULBERG, OM

NAMIKOSHI, M

EVANS, WR

CARMICHAEL, WW

RINEHART, KL

机构：

[1] NORWEGIAN INST WATER RES,N-0808 OSLO 8,NORWAY

[2] UNIV ILLINOIS,ROGER ADAMS LAB,URBANA,IL 61801

[3] WRIGHT STATE UNIV,DEPT BIOL SCI,DAYTON,OH 45435

来源：

TOXICON | 1992年 / 30卷 / 11期

关键词：

D O I：

10.1016/0041-0101(92)90522-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cultured cells of Anabaena flos-aquae strain CYA 83/1, isolated from Lake Edlandsvatn, Norway, produced two microcystin mono-methyl ester derivatives (1 and 2) at the D-Glu unit in addition to microcystin-LR (3), [D-Asp3]microcystin-LR (4), microcystin-RR (5), and [D-Asp3]microcystin-RR (6). Structures of these compounds were assigned based on their amino acid analysis with a Waters Pico Tag HPLC system plus fast atom bombardment mass spectrometry (FABMS), including tandem FABMS, analysis on the two new microcystins, [D-Glu(OCH3)6]microcystin-LR (1) and [D-Asp3, D-Glu(OCH3)6]microcystin-LR (2). Toxicity data were not obtained for 1 and 2 because of the small amounts isolated from the cells.

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页码：1465 / 1471

页数：7

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