SYNTHESIS AND INVITRO ANTI-PROTOZOAN ACTIVITY OF NEW 5-NITROTHIOPHENE OXIME ETHER DERIVATIVES

被引：49

作者：

DELMAS, F

GASQUET, M

TIMONDAVID, P

MADADI, N

VANELLE, P

VAILLE, A

MALDONADO, J

机构：

[1] FAC PHARM MARSEILLE,CHIM ORGAN LAB,27 BD JEAN MOULIN,F-13385 MARSEILLE 5,FRANCE

[2] FAC PHARM MARSEILLE,PARASITOL LAB,F-13385 MARSEILLE 5,FRANCE

[3] FAC PHARM MARSEILLE,PHARMACODYNAM LAB,F-13385 MARSEILLE 5,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 01期

关键词：

OXIME ETHERS; NITROTHIOPHENE DERIVATIVES; ANTI-PROTOZOAN ACTIVITY;

D O I：

10.1016/0223-5234(93)90075-P

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a part of a research project on anti-protozoan agents, various novel oxime ether derivatives were prepared in good yields from 2-thiophenecarboxaldehyde or 5-nitro-2-thiophene-carboxaldehyde. These compounds were evaluated as potential anti-protozoan compounds and some derivatives were found to be more active than the reference drugs.

引用

页码：23 / 27

页数：5

共 18 条

[1]

AUDIBERT P, 1979, ANN PHARM FR, V37, P483

[2] CULTIVATION IN A SEMI-DEFINED MEDIUM OF ANIMAL INFECTIVE FORMS OF TRYPANOSOMA-BRUCEI, TRYPANOSOMA-EQUIPERDUM, TRYPANOSOMA-EVANSI, TRYPANOSOMA-RHODESIENSE AND T-GAMBIENSE [J].