SYNTHESIS OF 6-[F-18] AND 4-[F-18]FLUORO-L-M-TYROSINES VIA REGIOSELECTIVE RADIOFLUORODESTANNYLATION

被引：40

作者：

NAMAVARI, M

SATYAMURTHY, N

PHELPS, ME

BARRIO, JR

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,DIV NUCL MED & BIOPHYS,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,NUCL MED LAB,LOS ANGELES,CA 90024

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 03期

关键词：

D O I：

10.1016/0969-8043(93)90165-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-M-tyrosine derivative 6 with [F-18]F2 and [F-18]acetyl hypofluorite afforded, after acid hydrolysis, 6-[F-18]fluoro-L-M-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[F-18]fluoro-L-m-tyrosine (13a) was synthesized in 11% radiochemical yield from the corresponding 4-trimethylstannyl-L-m-tyrosine derivative 11 using [F-18]F2. The structural analyses of precursors (6, 11), intermediates, and the final products (after F-18 decay), were carried out by H-1, C-13, F-19, Sn-119-NMR and high resolution mass spectroscopy.

引用

页码：527 / 536

页数：10

共 28 条

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