INTERFERON-MEDIATED INTRACELLULAR SIGNALING - MODULATION OF DIFFERENT PHOSPHOLIPASE ACTIVITIES IN BURKITT-LYMPHOMA CELLS

被引：6

作者：

CATALDI, A

RANA, R

DIPRIMIO, R

BAREGGI, R

LISIO, R

TOTO, N

MISCIA, S

机构：

[1] UNIV CHIETI,IST MORFOL UMANA NORMALE,VIA VESTINI 6,I-66100 CHIETI,ITALY

[2] UNIV TRIESTE,IST ANAT UMANA NORMALE,TRIESTE,ITALY

来源：

FEBS LETTERS | 1992年 / 313卷 / 03期

关键词：

INTERFERON; PHOSPHOLIPASE; DAUDI CELL;

D O I：

10.1016/0014-5793(92)81193-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.

引用

页码：210 / 212

页数：3

共 18 条

[1] INOSITOL PHOSPHATES AND CELL SIGNALING
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1989, 341 (6239) : 197 - 205
[2] BILLAH MM, 1989, J BIOL CHEM, V264, P17069
[3] THE REGULATION AND CELLULAR FUNCTIONS OF PHOSPHATIDYLCHOLINE HYDROLYSIS
BILLAH, MM
ANTHES, JC
[J]. BIOCHEMICAL JOURNAL, 1990, 269 (02) : 281 - 291
[4] BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[5] CATALDI A, 1990, FEBS LETT, V269, P464
[6] RAPID CHANGES IN PHOSPHOLIPID-METABOLISM IN THE NUCLEI OF SWISS 3T3 CELLS INDUCED BY TREATMENT OF THE CELLS WITH INSULIN-LIKE GROWTH FACTOR-I
COCCO, L
MARTELLI, AM
GILMOUR, RS
OGNIBENE, A
MANZOLI, FA
IRVINE, RF
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (03) : 1266 - 1272
[7] MASS MEASUREMENT OF INOSITOL 1,4,5-TRISPHOSPHATE AND SN-1,2-DIACYLGLYCEROL IN BOMBESIN-STIMULATED SWISS 3T3 MOUSE FIBROBLASTS
COOK, SJ
PALMER, S
PLEVIN, R
WAKELAM, MJO
[J]. BIOCHEMICAL JOURNAL, 1990, 265 (02) : 617 - 620
[8] The role of phospholipases and phospholipid-derived signals in cell activation
Ferguson, James E.
Hanley, Michael R.
[J]. CURRENT OPINION IN CELL BIOLOGY, 1991, 3 (02) : 206 - 212
[9] TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF INTERFERON-INDUCED GENE-EXPRESSION IN HUMAN-CELLS
FRIEDMAN, RL
MANLY, SP
MCMAHON, M
KERR, IM
STARK, GR
[J]. CELL, 1984, 38 (03) : 745 - 755
[10] SIGNAL TRANSDUCTION BY INTERFERON-ALPHA THROUGH ARACHIDONIC-ACID METABOLISM
HANNIGAN, GE
WILLIAMS, BRG
[J]. SCIENCE, 1991, 251 (4990) : 204 - 207

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