INTERFERON-MEDIATED INTRACELLULAR SIGNALING - MODULATION OF DIFFERENT PHOSPHOLIPASE ACTIVITIES IN BURKITT-LYMPHOMA CELLS

被引：6

作者：

CATALDI, A

RANA, R

DIPRIMIO, R

BAREGGI, R

LISIO, R

TOTO, N

MISCIA, S

机构：

[1] UNIV CHIETI,IST MORFOL UMANA NORMALE,VIA VESTINI 6,I-66100 CHIETI,ITALY

[2] UNIV TRIESTE,IST ANAT UMANA NORMALE,TRIESTE,ITALY

来源：

FEBS LETTERS | 1992年 / 313卷 / 03期

关键词：

INTERFERON; PHOSPHOLIPASE; DAUDI CELL;

D O I：

10.1016/0014-5793(92)81193-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.

引用

页码：210 / 212

页数：3

共 18 条

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